Virus-Specific Immunity in Neonatal and Adult Mouse Rotavirus Infection
نویسندگان
چکیده
منابع مشابه
Antibiotic treatment suppresses rotavirus infection and enhances specific humoral immunity.
BACKGROUND Rotavirus causes 500 000 deaths and millions of physician visits and hospitalizations per year, with worse outcomes and reduced vaccine efficacy in developing countries. We hypothesized that the gut microbiota might modulate rotavirus infection and/or antibody response and thus potentially play a role in such regional differences. METHODS The microbiota was ablated via germ-free or...
متن کاملNatural immunity to rotavirus infection in children.
Annual deaths in infants and young children due to rotavirus (RV) infection are around 100,000 in India and about 600,000 globally. Development of a vaccine for this disease is a high priority. The protective mechanisms for RV diarrhea in human are not fully understood, but it is known that children develop natural immunity against RV. Early exposure to RV results in most severe episode of diar...
متن کاملImmunity to rotavirus infection in mice.
Recent findings from our laboratory regarding the immune response of mice to rotavirus (a mucosal pathogen) show that although in most situations an acquired (T or B cell or both) response is necessary for elimination of primary rotavirus infection, unidentified innate mechanisms can also play a role in some mouse strains. Similar to what is seen with many other viruses, CD8+ T cells appear to ...
متن کاملImmunity and Virus Infection
What has evolved is a survey of radiation biology as it applies to the field of cancer which is a close approximation to a textbook on the subject. There is also a section on the medical applications of radiation which includes the experience of Gilbert H. Fletcher in the treatment of 1,500 cases of various malignant tumors with Cobalt-60 teletherapy and a 22-MEV Betatron. The major effort deal...
متن کاملCord blood and breast-milk antibodies in neonatal rotavirus infection.
Studies were carried out during an outbreak of rotavirus type 2 infection in a neonatal nursery to determine the protective role of antibodies in cord blood and breast milk. The range, distribution, and geometric mean titres of rotavirus-specific antibody in the cord blood were similar among rotavirus-positive and rotavirus-negative neonates, and the amount of virus excreted did not correlate w...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1983
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.39.2.917-927.1983